Free PTCB Sterile & Non-sterile Compounding Practice Test 2026 — CPhT Exam Questions

This free PTCB Sterile & Non-sterile Compounding practice test covers sterile (USP <797>) and non-sterile (USP <795>) compounding, hazardous drug handling (USP <800>), beyond-use dating, aseptic technique, and cleanroom standards. Each question includes a detailed explanation — perfect for PTCB / CPhT exam prep.

Key Topics in PTCB Sterile & Non-sterile Compounding

6 Free PTCB Sterile & Non-sterile Compounding Practice Questions with Answers

Sample Question 1 — Sterile and Non-sterile Compounding

Which of the following is the primary purpose of using a laminar airflow hood in sterile compounding?

  1. A. To maintain a sterile environment by filtering air (Correct answer)
  2. B. To provide additional workspace for compounding
  3. C. To store compounded medications temporarily
  4. D. To reduce the noise level in the compounding area

Correct answer: A

Explanation: A laminar airflow hood uses HEPA filters to create a controlled environment by continuously filtering air to remove contaminants, thus maintaining sterility.

Sample Question 2 — Sterile and Non-sterile Compounding

What is the recommended frequency for performing media fill tests for pharmacy personnel involved in sterile compounding?

  1. A. Every month
  2. B. Every six months (Correct answer)
  3. C. Annually
  4. D. Every two years

Correct answer: B

Explanation: Media fill tests are performed every six months to ensure that personnel can maintain aseptic techniques and the sterility of compounded preparations.

Sample Question 3 — Sterile and Non-sterile Compounding

In sterile compounding, what does the term 'First Air' refer to?

  1. A. The air initially filtered by the HVAC system
  2. B. Air that directly impacts the critical site of the product without obstruction (Correct answer)
  3. C. The outdoor air entering the compounding room
  4. D. The air that circulates within the laminar airflow hood

Correct answer: B

Explanation: First Air refers to the clean, HEPA-filtered air that flows unidirectionally onto the critical sites of the product and compounding personnel, which is crucial for maintaining sterility.

Sample Question 4 — Sterile and Non-sterile Compounding

Which personal protective equipment (PPE) is essential for both sterile and non-sterile compounding?

  1. A. Goggles
  2. B. Face mask
  3. C. Gloves (Correct answer)
  4. D. Gown

Correct answer: C

Explanation: Gloves are essential PPE for both sterile and non-sterile compounding to protect both the compounder and the preparation from cross-contamination.

Sample Question 5 — Sterile and Non-sterile Compounding

In non-sterile compounding, which method is commonly used to ensure uniform distribution of ingredients in a powder mixture?

  1. A. Sifting
  2. B. Levigation
  3. C. Trituration (Correct answer)
  4. D. Emulsification

Correct answer: C

Explanation: Trituration involves grinding powders together to ensure a uniform distribution of ingredients, which is crucial in non-sterile compounding for consistency and efficacy.

Sample Question 6 — Sterile and Non-sterile Compounding

Why is alcohol often used in the preparation of sterile compounds?

  1. A. It acts as a binding agent
  2. B. It enhances the potency of the medication
  3. C. It serves as a disinfectant (Correct answer)
  4. D. It neutralizes the compound's active ingredients

Correct answer: C

Explanation: Alcohol is commonly used as a disinfectant in sterile compounding to maintain a clean working environment and prevent contamination.

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